Cyclohexyl isocyanate → N-cyclohexyl-N'-[1,1-dimethyl-2-(3-nitro-7-phenylquinolin-4-ylamino)ethyl]urea

HRID 9409

반응식

HRID 9409 반응식
[N+:1]([C:4]1[CH:5]=[N:6][C:7]2[C:12]([C:13]=1[NH:14][CH2:15][C:16]([CH3:19])([NH2:18])[CH3:17])=[CH:11][CH:10]=[C:9]([C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1)[CH:8]=2)([O-:3])=[O:2].[CH:26]1([N:32]=[C:33]=[O:34])[CH2:31][CH2:30][CH2:29][CH2:28][CH2:27]1>ClCCl>[CH:26]1([NH:32][C:33]([NH:18][C:16]([CH3:19])([CH3:17])[CH2:15][NH:14][C:13]2[C:12]3[C:7](=[CH:8][C:9]([C:20]4[CH:21]=[CH:22][CH:23]=[CH:24][CH:25]=4)=[CH:10][CH:11]=3)[N:6]=[CH:5][C:4]=2[N+:1]([O-:3])=[O:2])=[O:34])[CH2:31][CH2:30][CH2:29][CH2:28][CH2:27]1

참가 물질

4

반응물 2

HCID 18502Cyclohexyl isocyanateHCID 86593761N1-(3-nitro-7-phenylquinolin-4-yl)-2-methylpropane-1,2-diamine

생성물 1

HCID 21984292N-cyclohexyl-N'-[1,1-dimethyl-2-(3-nitro-7-phenylquinolin-4-ylamino)ethyl]urea

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

A solution of N1-(3-nitro-7-phenylquinolin-4-yl)-2-methylpropane-1,2-diamine (3.56 g, 10.6 mmol) in dichloromethane (100 mL) was cooled to 0° C. Cyclohexyl isocyanate (3.00 mL, 23.5 mmol) was added over the course of a day, and the reaction was stirred at ambient temperature for three days. The solvent was removed under reduced pressure. Xylenes (3 cx 100 mL) were added and removed under reduced pressure to provide N-cyclohexyl-N′-[1,1-dimethyl-2-(3-nitro-7-phenylquinolin-4-ylamino)ethyl]urea as a yellow solid.

후처리

  1. customThe solvent was removed under reduced pressure
  2. additionXylenes (3 cx 100 mL) were added
  3. customremoved under reduced pressure

출처 및 근거

ORD 기록
ord-9d81f920428647a890f47a570c783a86
출처 데이터셋
uspto-grants-2006_08
특허 번호
US07091214B2

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