Ethoxyacetyl chloride → N-[7-bromo-4-(4-chlorobutylamino)quinolin-3-yl]-2-ethoxyacetamide hydrochloride

HRID 9418

반응식

HRID 9418 반응식
[Br:1][C:2]1[CH:11]=[C:10]2[C:5]([C:6]([NH:13][CH2:14][CH2:15][CH2:16][CH2:17][Cl:18])=[C:7]([NH2:12])[CH:8]=[N:9]2)=[CH:4][CH:3]=1.[CH2:19]([O:21][CH2:22][C:23](Cl)=[O:24])[CH3:20]>>[ClH:18].[Br:1][C:2]1[CH:11]=[C:10]2[C:5]([C:6]([NH:13][CH2:14][CH2:15][CH2:16][CH2:17][Cl:18])=[C:7]([NH:12][C:23](=[O:24])[CH2:22][O:21][CH2:19][CH3:20])[CH:8]=[N:9]2)=[CH:4][CH:3]=1

참가 물질

3

반응물 2

HCID 84189Ethoxyacetyl chlorideHCID 688179297-bromo-N4-(4-chlorobutyl)quinoline-3,4-diamine

생성물 1

HCID 21984236N-[7-bromo-4-(4-chlorobutylamino)quinolin-3-yl]-2-ethoxyacetamide hydrochloride

실험 절차

A modification of the method described in Part C of Examples 125–135 was used to treat 7-bromo-N4-(4-chlorobutyl)quinoline-3,4-diamine (7.25 g, 22.1 mmol) with ethoxyacetyl chloride (2.76 mL, 24.3 mmol). After the reaction was stirred for one hour, it was concentrated under reduced pressure to provide N-[7-bromo-4-(4-chlorobutylamino)quinolin-3-yl]-2-ethoxyacetamide hydrochloride as a yellow solid.

후처리

  1. concentrationit was concentrated under reduced pressure

출처 및 근거

ORD 기록
ord-5addcc65777f49a1b27a679dec305ec4
출처 데이터셋
uspto-grants-2006_08
특허 번호
US07091214B2

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