1-{2-[5-Bromo-4-(5-chlorothiophen-2-yl)pyrimidin-2-ylamino]ethyl}-5,5-dimethylimidazolidine-2,4-dione → tert-butyl 4-{4-(5-chlorothiophen-2-yl)-2-[2-(5,5-dimethyl-2,4-dioxoimidazolidin-1-yl)ethylamino]pyrimidin-5-yl}-1H-indole-1-carboxylate

반응식

[Br:1][c:2]1[c:3](-[c:20]2[s:21][c:22]([Cl:25])[cH:23][cH:24]2)[n:4][c:5]([NH:8][CH2:9][CH2:10][N:11]2[C:12](=[O:19])[NH:13][C:14](=[O:18])[C:15]2([CH3:16])[CH3:17])[n:6][cH:7]1.[CH3:26][C:27]1([CH3:28])[C:29]([CH3:30])([CH3:31])[O:32][B:33]([c:34]2[c:35]3[cH:36][cH:37][n:38]([C:43](=[O:44])[O:45][C:46]([CH3:47])([CH3:48])[CH3:49])[c:39]3[cH:40][cH:41][cH:42]2)[O:50]1>>[c:2]1(-[c:34]2[c:35]3[cH:36][cH:37][n:38]([C:43](=[O:44])[O:45][C:46]([CH3:47])([CH3:48])[CH3:49])[c:39]3[cH:40][cH:41][cH:42]2)[c:3](-[c:20]2[s:21][c:22]([Cl:25])[cH:23][cH:24]2)[n:4][c:5]([NH:8][CH2:9][CH2:10][N:11]2[C:12](=[O:19])[NH:13][C:14](=[O:18])[C:15]2([CH3:16])[CH3:17])[n:6][cH:7]1