5-Fluoro-6-(4-fluoro-benzylamino)-1,3-dihydro-indol-2-one → 2-[5-fluoro-6-(4-fluoro-benzylamino)-2-oxo-1,2-dihydro-indol-3-ylidenemethyl]-3-m ethyl-5-(2-morpholin-4-yl-ethyl)-5,6,7,8-tetrahydro-1H-pyrrolo[3,2-c]azepin-4-one

반응식

[CH3:1][c:2]1[c:3]([CH:21]=[O:22])[nH:4][c:5]2[c:6]1[C:7](=[O:20])[N:8]([CH2:12][CH2:13][N:14]1[CH2:15][CH2:16][O:17][CH2:18][CH2:19]1)[CH2:9][CH2:10][CH2:11]2.[F:23][c:24]1[cH:25][c:26]2[c:30]([cH:31][c:32]1[NH:33][CH2:34][c:35]1[cH:36][cH:37][c:38]([F:41])[cH:39][cH:40]1)[NH:29][C:28](=[O:42])[CH2:27]2>>[CH3:1][c:2]1[c:3]([CH:21]=[C:27]2[c:26]3[cH:25][c:24]([F:23])[c:32]([NH:33][CH2:34][c:35]4[cH:36][cH:37][c:38]([F:41])[cH:39][cH:40]4)[cH:31][c:30]3[NH:29][C:28]2=[O:42])[nH:4][c:5]2[c:6]1[C:7](=[O:20])[N:8]([CH2:12][CH2:13][N:14]1[CH2:15][CH2:16][O:17][CH2:18][CH2:19]1)[CH2:9][CH2:10][CH2:11]2