Dichloromethane → 4-(4-Amino-3-chloro-5-trifluoromethyl-phenyl)-3,3-bis-ethoxycarbonyl-butanoic acid

반응식

[Cl:40][CH2:41][Cl:42].[F:33][C:34]([F:35])([F:36])[C:37]([OH:38])=[O:39].[NH2:1][c:2]1[c:3]([Cl:32])[cH:4][c:5]([CH2:12][C:13]([CH2:14][C:15](=[O:16])[O:17][C:18]([CH3:19])([CH3:20])[CH3:21])([C:22](=[O:23])[O:24][CH2:25][CH3:26])[C:27](=[O:28])[O:29][CH2:30][CH3:31])[cH:6][c:7]1[C:8]([F:9])([F:10])[F:11]>>[NH2:1][c:2]1[c:3]([Cl:32])[cH:4][c:5]([CH2:12][C:13]([CH2:14][C:15](=[O:16])[OH:17])([C:22](=[O:23])[O:24][CH2:25][CH3:26])[C:27](=[O:28])[O:29][CH2:30][CH3:31])[cH:6][c:7]1[C:8]([F:9])([F:10])[F:11]

참가 물질

반응물 3

HCID 6344Dichloromethane

HCID 6422Trifluoroacetic acid

HCID 68590557Tert. butyl 4-(4-amino-3-chloro-5-trifluoromethyl-phenyl)-3,3-bis-ethoxycarbonyl-butyrate

생성물 1

HCID 221846134-(4-Amino-3-chloro-5-trifluoromethyl-phenyl)-3,3-bis-ethoxycarbonyl-butanoic acid

출처 및 근거

ORD 기록: ord-416856983d0448e8ba4aa5760cbca6cc
출처 데이터셋: Validation data from https://doi.org/10.1039/C8SC04228D
DOI: 10.1039/C8SC04228D

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