2-Amino-1-butanol → [4-amino-2-[[1-[3-(1-hydroxybutan-2-ylamino)propylsulfonyl]piperidin-4-yl]amino]pyrimidin-5-yl]-(2,3-difluoro-6-methoxyphenyl)methanone

HRID 944098노트

반응식

HRID 944098 반응식
[NH2:1][c:2]1[n:3][c:4]([NH:20][CH:21]2[CH2:22][CH2:23][N:24]([S:27](=[O:28])(=[O:29])[CH2:30][CH2:31][CH2:32][Cl:33])[CH2:25][CH2:26]2)[n:5][cH:6][c:7]1[C:8](=[O:9])[c:10]1[c:11]([F:19])[c:12]([F:18])[cH:13][cH:14][c:15]1[O:16][CH3:17].[NH2:34][CH:35]([CH2:36][OH:37])[CH2:38][CH3:39]>>[NH2:1][c:2]1[n:3][c:4]([NH:20][CH:21]2[CH2:22][CH2:23][N:24]([S:27](=[O:28])(=[O:29])[CH2:30][CH2:31][CH2:32][NH:34][CH:35]([CH2:36][OH:37])[CH2:38][CH3:39])[CH2:25][CH2:26]2)[n:5][cH:6][c:7]1[C:8](=[O:9])[c:10]1[c:11]([F:19])[c:12]([F:18])[cH:13][cH:14][c:15]1[O:16][CH3:17]

참가 물질

3

반응물 2

HCID 221292-Amino-1-butanolHCID 9983584[4-Amino-2-[1-(3-chloro-propane-1-sulfonyl)-piperidin-4-ylamino]-pyrimidin-5-yl]-(2,3-difluoro-6-methoxy-phenyl)-methanone

생성물 1

HCID 178454527[4-amino-2-[[1-[3-(1-hydroxybutan-2-ylamino)propylsulfonyl]piperidin-4-yl]amino]pyrimidin-5-yl]-(2,3-difluoro-6-methoxyphenyl)methanone

출처 및 근거

ORD 기록
ord-eac8c61d0a054774ab7c734634ba61cd
출처 데이터셋
Validation data from https://doi.org/10.1039/C8SC04228D

반응 노트

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