tert-Butyl bromoacetate → Tert-butyl 2-[1-[2-(3-aminopropyl)-5-(2,5-difluorophenyl)-2-phenyl-1,3,4-thiadiazol-3-yl]-1-oxopropan-2-yl]oxyacetate

반응식

[Br:1][CH2:2][C:3](=[O:4])[O:5][C:6]([CH3:7])([CH3:8])[CH3:9].[NH2:10][CH2:11][CH2:12][CH2:13][C:14]1([c:33]2[cH:34][cH:35][cH:36][cH:37][cH:38]2)[S:15][C:16]([c:25]2[c:26]([F:32])[cH:27][cH:28][c:29]([F:31])[cH:30]2)=[N:17][N:18]1[C:19]([CH:20]([CH3:21])[O:22][CH3:23])=[O:24]>>[CH2:2]([C:3](=[O:4])[O:5][C:6]([CH3:7])([CH3:8])[CH3:9])[O:22][CH:20]([C:19]([N:18]1[C:14]([CH2:13][CH2:12][CH2:11][NH2:10])([c:33]2[cH:34][cH:35][cH:36][cH:37][cH:38]2)[S:15][C:16]([c:25]2[c:26]([F:32])[cH:27][cH:28][c:29]([F:31])[cH:30]2)=[N:17]1)=[O:24])[CH3:21]

참가 물질

반응물 2

HCID 79177tert-Butyl bromoacetate

HCID 672147371-[2-(3-Aminopropyl)-5-(2,5-difluorophenyl)-2-phenyl-1,3,4-thiadiazol-3-yl]-2-methoxypropan-1-one

생성물 1

HCID 69492915Tert-butyl 2-[1-[2-(3-aminopropyl)-5-(2,5-difluorophenyl)-2-phenyl-1,3,4-thiadiazol-3-yl]-1-oxopropan-2-yl]oxyacetate

출처 및 근거

ORD 기록: ord-413aec90ffde440e949fd0598b9d2909
출처 데이터셋: Validation data from https://doi.org/10.1039/C8SC04228D
DOI: 10.1039/C8SC04228D

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