Triethylamine → 1-(6-Benzyl-3-nitroquinolin-4-ylamino)-2-methylpropan-2-ol

HRID 9458

반응식

HRID 9458 반응식
[NH2:1][CH2:2][C:3]([CH3:6])([OH:5])[CH3:4].[CH2:7]([C:14]1[CH:23]=[C:22]2[C:17]([C:18](Cl)=[C:19]([N+:24]([O-:26])=[O:25])[CH:20]=[N:21]2)=[CH:16][CH:15]=1)[C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1.[CH2:28]([C:35]1[CH:36]=[C:37]2[C:42](=[CH:43][CH:44]=1)[N:41]=[CH:40][C:39]([N+:45]([O-:47])=[O:46])=[C:38]2Cl)[C:29]1[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=1.C(N(CC)CC)C>ClCCl>[CH2:7]([C:14]1[CH:23]=[C:22]2[C:17]([C:18]([NH:1][CH2:2][C:3]([CH3:6])([OH:5])[CH3:4])=[C:19]([N+:24]([O-:26])=[O:25])[CH:20]=[N:21]2)=[CH:16][CH:15]=1)[C:8]1[CH:9]=[CH:10][CH:11]=[CH:12][CH:13]=1.[CH2:28]([C:35]1[CH:36]=[C:37]2[C:42](=[CH:43][CH:44]=1)[N:41]=[CH:40][C:39]([N+:45]([O-:47])=[O:46])=[C:38]2[NH:1][CH2:2][C:3]([CH3:6])([OH:5])[CH3:4])[C:29]1[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=1

참가 물질

7

반응물 4

HCID 8471TriethylamineHCID 951022-Propanol, 1-amino-2-methyl-HCID 219841937-Benzyl-4-chloro-3-nitroquinolineHCID 219842266-Benzyl-4-chloro-3-nitroquinoline

생성물 2

HCID 219844101-(6-Benzyl-3-nitroquinolin-4-ylamino)-2-methylpropan-2-olHCID 219844521-(7-Benzyl-3-nitroquinolin-4-ylamino)-2-methylpropan-2-ol

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

Under a nitrogen atmosphere, 1-amino-2-methylpropan-2-ol (1.2 equivalents) was added to a 0.2 M solution of 7-benzyl-4-chloro-3-nitroquinoline or 6-benzyl-4-chloro-3-nitroquinoline (1 equivalent) and triethylamine (3 equivalents) in dichloromethane, and the reaction was stirred overnight at ambient temperature. The volatiles were removed under reduced pressure, and the residue was stirred with water (50 mL) for one hour. The resulting yellow solid was isolated by filtration and washed with water to provide 1-(7-benzyl-3-nitroquinolin-4-ylamino)-2-methylpropan-2-ol or 1-(6-benzyl-3-nitroquinolin-4-ylamino)-2-methylpropan-2-ol, respectively.

후처리

  1. customThe volatiles were removed under reduced pressure
  2. stirringthe residue was stirred with water (50 mL) for one hour
  3. customThe resulting yellow solid was isolated by filtration
  4. washwashed with water

출처 및 근거

ORD 기록
ord-a26247a753df407cb8aa5733bcc350c4
출처 데이터셋
uspto-grants-2006_08
특허 번호
US07091214B2

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