Dichloromethane → N-[6-(8-acetyloctahydro-2H-pyrazino[1,2-a]pyrazin-2-yl)-4-(4-fluoro-2-methylphenyl)-3-pyridinyl]-2-[3,5-bis(trifluoromethyl)phenyl]-N,2-dimethylpropanamide

반응식

[CH3:46][CH2:47][N:48]([CH2:49][CH3:50])[CH2:51][CH3:52].[CH3:53][C:54]([Cl:55])=[O:56].[Cl:57][CH2:58][Cl:59].[F:1][C:2]([c:3]1[cH:4][c:5]([C:13]([C:14](=[O:15])[N:16]([CH3:17])[c:18]2[cH:19][n:20][c:21]([N:32]3[CH2:33][CH:34]4[N:35]([CH2:36][CH2:37]3)[CH2:38][CH2:39][NH:40][CH2:41]4)[cH:22][c:23]2-[c:24]2[c:25]([CH3:31])[cH:26][c:27]([F:30])[cH:28][cH:29]2)([CH3:42])[CH3:43])[cH:6][c:7]([C:9]([F:10])([F:11])[F:12])[cH:8]1)([F:44])[F:45]>>[F:1][C:2]([c:3]1[cH:4][c:5]([C:13]([C:14](=[O:15])[N:16]([CH3:17])[c:18]2[cH:19][n:20][c:21]([N:32]3[CH2:33][CH:34]4[N:35]([CH2:36][CH2:37]3)[CH2:38][CH2:39][N:40]([C:54]([CH3:53])=[O:56])[CH2:41]4)[cH:22][c:23]2-[c:24]2[c:25]([CH3:31])[cH:26][c:27]([F:30])[cH:28][cH:29]2)([CH3:42])[CH3:43])[cH:6][c:7]([C:9]([F:10])([F:11])[F:12])[cH:8]1)([F:44])[F:45]