Ammonia → 5-amino-2-(2,6-difluorophenyl)-N-[1-methyl-5-[3-(trifluoromethyl)piperazin-1-yl]pyrazol-4-yl]-1,3-thiazole-4-carboxamide

반응식

[Cl:49][CH2:50][Cl:51].[F:1][c:2]1[c:3](-[c:9]2[s:10][c:11]([NH:33][C:34](=[O:35])[O:36][C:37]([CH3:38])([CH3:39])[CH3:40])[c:12]([C:14]([NH:15][c:16]3[cH:17][n:18][n:19]([CH3:31])[c:20]3[N:21]3[CH2:22][CH:23]([C:27]([F:28])([F:29])[F:30])[NH:24][CH2:25][CH2:26]3)=[O:32])[n:13]2)[c:4]([F:8])[cH:5][cH:6][cH:7]1.[F:42][C:43]([F:44])([F:45])[C:46]([OH:47])=[O:48].[NH3:41]>>[F:1][c:2]1[c:3](-[c:9]2[s:10][c:11]([NH2:33])[c:12]([C:14]([NH:15][c:16]3[cH:17][n:18][n:19]([CH3:31])[c:20]3[N:21]3[CH2:22][CH:23]([C:27]([F:28])([F:29])[F:30])[NH:24][CH2:25][CH2:26]3)=[O:32])[n:13]2)[c:4]([F:8])[cH:5][cH:6][cH:7]1