Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
5-((3-Bromophenylamino)methylene)-2,2-di-methyl-1,3-dioxane-4,6-dione → 5-Bromoquinolin-4-ol
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 5-((3-Bromophenylamino)methylene)-2,2-di-methyl-1,3-dioxane-4,6-dione | HCID 17252219 | — |
| 용매 | 1,1'-Biphenyl, mixt. with 1,1'-oxybis(benzene) | HCID 24670 | — |
| 생성물 | 5-Bromoquinolin-4-ol | HCID 178418724 | — |
| 생성물 | HCID 178418765 | HCID 178418765 | — |
반응 단계
5-[(3-Bromophenylamino)methylene]-2,2-dimethyl-[1,3]dioxane-4,6-dione (32.6 g, 0.100 mol) was heated at 250° C. in DOWTHERM A heat transfer fluid for one hour, and then the reaction was allowed to cool to ambient temperature. A precipitate formed upon cooling and was isolated by filtration and washed with diethyl ether to provide 7-bromoquinolin-4-ol and 5-bromoquinolin-4-ol in a 2:1 ratio.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07091214B2 |
| 출처 데이터셋 | uspto-grants-2006_08 |
| ORD ID | ord-b1f865ef25a04e39839832f0be237929 |
| 출처 메모 | uspto-grants-2006_08 |