Dichloromethane → Tert-butyl 4-{[2-({3-(acetylamino)-5-[2-(1-hydroxycyclobutyl)-1,3-thiazol-5-yl]phenyl}amino)pyrimidin-4-yl]oxy}piperidine-1-carboxylate

반응식

[CH3:39][C:40]([Cl:41])=[O:42].[CH3:43][CH2:44][N:45]([CH2:46][CH3:47])[CH2:48][CH3:49].[Cl:50][CH2:51][Cl:52].[NH2:1][c:2]1[cH:3][c:4]([NH:18][c:19]2[n:20][cH:21][cH:22][c:23]([O:25][CH:26]3[CH2:27][CH2:28][N:29]([C:32](=[O:33])[O:34][C:35]([CH3:36])([CH3:37])[CH3:38])[CH2:30][CH2:31]3)[n:24]2)[cH:5][c:6](-[c:8]2[cH:9][n:10][c:11]([C:13]3([OH:17])[CH2:14][CH2:15][CH2:16]3)[s:12]2)[cH:7]1>>[NH:1]([c:2]1[cH:3][c:4]([NH:18][c:19]2[n:20][cH:21][cH:22][c:23]([O:25][CH:26]3[CH2:27][CH2:28][N:29]([C:32](=[O:33])[O:34][C:35]([CH3:36])([CH3:37])[CH3:38])[CH2:30][CH2:31]3)[n:24]2)[cH:5][c:6](-[c:8]2[cH:9][n:10][c:11]([C:13]3([OH:17])[CH2:14][CH2:15][CH2:16]3)[s:12]2)[cH:7]1)[C:40]([CH3:39])=[O:42]