1H-1,2,4-Triazole → 1-(3,4,4-trifluoro-1-oxo-3-butenyl)-1H-1,2,4-triazole
반응식
[NH:1]1[CH:5]=[N:4][CH:3]=[N:2]1.[F:6][C:7](=[C:12]([F:14])[F:13])[CH2:8][C:9](Cl)=[O:10]>C(OCC)(=O)C>[F:6][C:7](=[C:12]([F:14])[F:13])[CH2:8][C:9]([N:1]1[CH:5]=[N:4][CH:3]=[N:2]1)=[O:10]참가 물질
4
실험 절차
To a solution of 1,2,4-triazole (1.38 g, 20 mmol) in ethyl acetate (100 mL) was added 3,4,4-trifluoro-3-butenoyl chloride (1.59 g, 10 mmol) at r.t. with stirring. The mixture was stirred for 30 min and filtered. The residue obtained after evaporation of the solvent was redissolved in dichloromethane (25 mL) and filtered. Evaporation of the solvent gave 1.8 g (94%) of the desired product as a dear oil.
후처리
- stirringThe mixture was stirred for 30 min
- filtrationfiltered
- customThe residue obtained
- customafter evaporation of the solvent
- dissolutionwas redissolved in dichloromethane (25 mL)
- filtrationfiltered
- customEvaporation of the solvent
출처 및 근거
- ORD 기록
- ord-0c18d3271e484f0f9ae2b826de5610c7
- 출처 데이터셋
- uspto-grants-1998_03
- 특허 번호
- US05723470
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