1-((4R)-2,2-dimethyl-1,3-dioxolan-4-yl)methanamine → HCID 68817756, 화합물

HRID 9483노트

반응식

HRID 9483 반응식
[Br:1][C:2]1[CH:11]=[C:10]2[C:5]([C:6](Cl)=[C:7]([N+:12]([O-:14])=[O:13])[CH:8]=[N:9]2)=[CH:4][CH:3]=1.[CH3:16][C:17]1([CH3:24])[O:21][C@H:20]([CH2:22][NH2:23])[CH2:19][O:18]1>>[Br:1][C:2]1[CH:11]=[C:10]2[C:5]([C:6]([NH:23][CH2:22][C@@H:20]3[CH2:19][O:18][C:17]([CH3:24])([CH3:16])[O:21]3)=[C:7]([N+:12]([O-:14])=[O:13])[CH:8]=[N:9]2)=[CH:4][CH:3]=1

참가 물질

3

반응물 2

HCID 101540731-((4R)-2,2-dimethyl-1,3-dioxolan-4-yl)methanamineHCID 219843617-Bromo-4-chloro-3-nitroquinoline

생성물 1

HCID 68817756HCID 68817756, 화합물수율 88.4%

실험 절차

7-Bromo-4-chloro-3-nitroquinoline (22.00 g, 76.52 mmol) was treated with (R)-2,2-dimethyl-1,3-dioxolane-4-methanamine (11.61 g, 114.8 mmol) according to the method described in Part A of Examples 152–156. The crude product was triturated with water (200 mL), isolated by filtration, washed with water, dried, and suspended in diethyl ether (100 mL). The suspension was sonicated, and the resulting solid was isolated by filtration, and dried for four hours in a vacuum oven at 40° C. to provide 25.84 g of (R)-(7-bromo-3-nitroquinolin-4-yl)-(2,2-dimethyl-1,3-dioxolan-4-ylmethyl)amine as a yellow solid, mp 136–137° C.

후처리

  1. customThe crude product was triturated with water (200 mL)
  2. customisolated by filtration
  3. washwashed with water
  4. customdried
  5. customThe suspension was sonicated
  6. customthe resulting solid was isolated by filtration
  7. customdried for four hours in a vacuum oven at 40° C.

출처 및 근거

ORD 기록
ord-6ce4ecf087dd4b5e9dfdb947815f2d30
출처 데이터셋
uspto-grants-2006_08
특허 번호
US07091214B2

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