2-Aminopyrimidine-5-boronic acid, pinacol ester → 5-{3-[4-(3-Methyl-4-trifluoromethyl-phenyl)-6-trifluoromethyl-pyrimidin-2-yl]-phenyl}-pyrimidin-2-ylamine

반응식

[Br:1][c:2]1[cH:3][c:4](-[c:8]2[n:9][c:10]([C:25]([F:26])([F:27])[F:28])[cH:11][c:12](-[c:14]3[cH:15][c:16]([CH3:24])[c:17]([C:20]([F:21])([F:22])[F:23])[cH:18][cH:19]3)[n:13]2)[cH:5][cH:6][cH:7]1.[NH2:29][c:30]1[n:31][cH:32][c:33]([B:36]2[O:37][C:38]([CH3:39])([CH3:40])[C:41]([CH3:42])([CH3:43])[O:44]2)[cH:34][n:35]1>>[c:2]1(-[c:33]2[cH:32][n:31][c:30]([NH2:29])[n:35][cH:34]2)[cH:3][c:4](-[c:8]2[n:9][c:10]([C:25]([F:26])([F:27])[F:28])[cH:11][c:12](-[c:14]3[cH:15][c:16]([CH3:24])[c:17]([C:20]([F:21])([F:22])[F:23])[cH:18][cH:19]3)[n:13]2)[cH:5][cH:6][cH:7]1

참가 물질

반응물 2

HCID 177502122-Aminopyrimidine-5-boronic acid, pinacol ester

HCID 574687662-(3-Bromophenyl)-4-(3-methyl-4-trifluoromethyl-phenyl)-6-trifluoromethyl-pyrimidine

생성물 1

HCID 602094015-{3-[4-(3-Methyl-4-trifluoromethyl-phenyl)-6-trifluoromethyl-pyrimidin-2-yl]-phenyl}-pyrimidin-2-ylamine

출처 및 근거

ORD 기록: ord-5c33c268a3014e48bf6f067f5c6bc26c
출처 데이터셋: Validation data from https://doi.org/10.1039/C8SC04228D
DOI: 10.1039/C8SC04228D

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