Tetrahydrofuran → 8-Tert-butyl-1-oxa-2-azaspiro[4.5]dec-2-ene-3-carboxylic acid-(3-fluoro-4-methanesulphonylaminophenyl)amide

반응식

[C:1]([CH3:2])([CH3:3])([CH3:4])[CH:5]1[CH2:6][CH2:7][C:8]2([CH2:9][C:10]([C:13](=[O:14])[OH:15])=[N:11][O:12]2)[CH2:16][CH2:17]1.[CH2:31]1[O:32][CH2:33][CH2:34][CH2:35]1.[NH2:18][c:19]1[cH:20][c:21]([F:30])[c:22]([NH:25][S:26](=[O:27])(=[O:28])[CH3:29])[cH:23][cH:24]1>>[C:1]([CH3:2])([CH3:3])([CH3:4])[CH:5]1[CH2:6][CH2:7][C:8]2([CH2:9][C:10]([C:13](=[O:15])[NH:18][c:19]3[cH:20][c:21]([F:30])[c:22]([NH:25][S:26](=[O:27])(=[O:28])[CH3:29])[cH:23][cH:24]3)=[N:11][O:12]2)[CH2:16][CH2:17]1

참가 물질

반응물 3

HCID 8028Tetrahydrofuran

HCID 12254684N-(4-amino-2-fluorophenyl)methanesulfonamide

HCID 579514498-Tert-butyl-1-oxa-2-azaspiro[4.5]dec-2-ene-3-carboxylic acid

생성물 1

HCID 673166198-Tert-butyl-1-oxa-2-azaspiro[4.5]dec-2-ene-3-carboxylic acid-(3-fluoro-4-methanesulphonylaminophenyl)amide

출처 및 근거

ORD 기록: ord-9792eef2149c460bbd63063ca02eac45
출처 데이터셋: Validation data from https://doi.org/10.1039/C8SC04228D
DOI: 10.1039/C8SC04228D

반응 노트

불러오는 중…