Piperidin-4-ol → tert-Butyl-5-(4-hydroxy-piperidin-1-yl)-1H-pyrazole-4-carboxylic acid adamantan-2-ylamide

반응식

[CH:1]12[CH:2]([NH:11][C:12](=[O:13])[c:14]3[cH:15][n:16][n:17]([C:20]([CH3:21])([CH3:22])[CH3:23])[c:18]3[Cl:19])[CH:3]3[CH2:4][CH:5]([CH2:6][CH:7]([CH2:8]1)[CH2:9]3)[CH2:10]2.[NH:24]1[CH2:25][CH2:26][CH:27]([OH:30])[CH2:28][CH2:29]1>>[CH:1]12[CH:2]([NH:11][C:12](=[O:13])[c:14]3[cH:15][n:16][n:17]([C:20]([CH3:21])([CH3:22])[CH3:23])[c:18]3[N:24]3[CH2:25][CH2:26][CH:27]([OH:30])[CH2:28][CH2:29]3)[CH:3]3[CH2:4][CH:5]([CH2:6][CH:7]([CH2:8]1)[CH2:9]3)[CH2:10]2

참가 물질

반응물 2

HCID 79341Piperidin-4-ol

HCID 250144171-tert-butyl-5-chloro-1H-pyrazole-4-carboxylic acid adamantan-2-ylamide

생성물 1

HCID 25014419tert-Butyl-5-(4-hydroxy-piperidin-1-yl)-1H-pyrazole-4-carboxylic acid adamantan-2-ylamide

출처 및 근거

ORD 기록: ord-4c9d638f7e1a4ea68077c6c290fd02ae
출처 데이터셋: Training data from https://doi.org/10.1039/C8SC04228D (2/10)
DOI: 10.1039/C8SC04228D

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