Dichloromethane → 5-Chloromethyl-4-cyclopropyl-6-methoxymethyl-2-(4-trifluoromethyl-phenyl)-pyrimidine

반응식

[CH:1]1([c:4]2[n:5][c:6](-[c:15]3[cH:16][cH:17][c:18]([C:21]([F:22])([F:23])[F:24])[cH:19][cH:20]3)[n:7][c:8]([CH2:12][O:13][CH3:14])[c:9]2[CH2:10][OH:11])[CH2:2][CH2:3]1.[Cl:29][CH2:30][Cl:31].[S:25]([Cl:26])([Cl:27])=[O:28]>>[CH:1]1([c:4]2[n:5][c:6](-[c:15]3[cH:16][cH:17][c:18]([C:21]([F:22])([F:23])[F:24])[cH:19][cH:20]3)[n:7][c:8]([CH2:12][O:13][CH3:14])[c:9]2[CH2:10][Cl:27])[CH2:2][CH2:3]1

참가 물질

반응물 3

HCID 6344Dichloromethane

HCID 24386Thionyl Chloride

HCID 21935658[4-Cyclopropyl-6-methoxymethyl-2-(4-trifluoromethyl-phenyl)-pyrimidin-5-yl]-methanol

생성물 1

HCID 219357905-Chloromethyl-4-cyclopropyl-6-methoxymethyl-2-(4-trifluoromethyl-phenyl)-pyrimidine

출처 및 근거

ORD 기록: ord-a6e10878d5e445cdae15374e39491a15
출처 데이터셋: Validation data from https://doi.org/10.1039/C8SC04228D
DOI: 10.1039/C8SC04228D

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