4-Methylcyclohexylamine → Tert-butyl 3-((2-(cis-4-methylcyclohexylamino)-5-bromopyrimidin-4-yloxy)methyl)azetidine-1-carboxylate

반응식

[Br:1][c:2]1[c:3]([O:9][CH2:10][CH:11]2[CH2:12][N:13]([C:15](=[O:16])[O:17][C:18]([CH3:19])([CH3:20])[CH3:21])[CH2:14]2)[n:4][c:5]([Cl:8])[n:6][cH:7]1.[CH3:22][CH:23]1[CH2:24][CH2:25][CH:26]([NH2:29])[CH2:27][CH2:28]1>>[Br:1][c:2]1[c:3]([O:9][CH2:10][CH:11]2[CH2:12][N:13]([C:15](=[O:16])[O:17][C:18]([CH3:19])([CH3:20])[CH3:21])[CH2:14]2)[n:4][c:5]([NH:29][CH:26]2[CH2:25][CH2:24][CH:23]([CH3:22])[CH2:28][CH2:27]2)[n:6][cH:7]1

참가 물질

반응물 2

HCID 806044-Methylcyclohexylamine

HCID 86761726Tert-butyl 3-((5-bromo-2-chloropyrimidin-4-yloxy)methyl)azetidine-1-carboxylate

생성물 1

HCID 71108144Tert-butyl 3-((2-(cis-4-methylcyclohexylamino)-5-bromopyrimidin-4-yloxy)methyl)azetidine-1-carboxylate

출처 및 근거

ORD 기록: ord-6162eb8459384a58bf9c6435c103565d
출처 데이터셋: Validation data from https://doi.org/10.1039/C8SC04228D
DOI: 10.1039/C8SC04228D

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