5-Bromo-2-chloropyrimidine → N-(4-(1,3-benzodioxol-5-yl)-3-{2-[(5-bromo-2-pyrimidinyl)oxy]ethoxy}-1-methyl-1H-pyrazol-5-yl)-4-(tert-butyl)benzenesulfonamide

반응식

[Br:1][c:2]1[cH:3][n:4][c:5]([Cl:8])[n:6][cH:7]1.[O:9]1[CH2:10][O:11][c:12]2[c:13]1[cH:14][cH:15][c:16](-[c:18]1[c:19]([O:38][CH2:39][CH2:40][OH:41])[n:20][n:21]([CH3:37])[c:22]1[NH:23][S:24](=[O:25])(=[O:26])[c:27]1[cH:28][cH:29][c:30]([C:33]([CH3:34])([CH3:35])[CH3:36])[cH:31][cH:32]1)[cH:17]2>>[Br:1][c:2]1[cH:3][n:4][c:5]([O:41][CH2:40][CH2:39][O:38][c:19]2[c:18](-[c:16]3[cH:15][cH:14][c:13]4[c:12]([cH:17]3)[O:11][CH2:10][O:9]4)[c:22]([NH:23][S:24](=[O:25])(=[O:26])[c:27]3[cH:28][cH:29][c:30]([C:33]([CH3:34])([CH3:35])[CH3:36])[cH:31][cH:32]3)[n:21]([CH3:37])[n:20]2)[n:6][cH:7]1

참가 물질

반응물 2

HCID 6066655-Bromo-2-chloropyrimidine

HCID 22282036N-[4-(1,3-benzodioxol-5-yl)-3-(2-hydroxyethoxy)-1-methyl-1H-pyrazol-5-yl]-4-(tert-butyl)benzenesulfonamide

생성물 1

HCID 9960849N-(4-(1,3-benzodioxol-5-yl)-3-{2-[(5-bromo-2-pyrimidinyl)oxy]ethoxy}-1-methyl-1H-pyrazol-5-yl)-4-(tert-butyl)benzenesulfonamide

출처 및 근거

ORD 기록: ord-d1ea4ca59fc34820b7e8a0f8bcadfbf7
출처 데이터셋: Validation data from https://doi.org/10.1039/C8SC04228D
DOI: 10.1039/C8SC04228D

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