Ethyl bromoacetate → Ethyl 2-(4-acetyl-2-methylphenoxy)acetate

HRID 9624

반응식

HRID 9624 반응식
[OH:1][C:2]1[CH:7]=[CH:6][C:5]([C:8](=[O:10])[CH3:9])=[CH:4][C:3]=1[CH3:11].C(=O)([O-])[O-].[Cs+].[Cs+].Br[CH2:19][C:20]([O:22][CH2:23][CH3:24])=[O:21]>C(#N)C>[CH2:23]([O:22][C:20](=[O:21])[CH2:19][O:1][C:2]1[CH:7]=[CH:6][C:5]([C:8](=[O:10])[CH3:9])=[CH:4][C:3]=1[CH3:11])[CH3:24]

참가 물질

5

반응물 3

HCID 7748Ethyl bromoacetate2회HCID 10796Cesium carbonate2회HCID 701354'-Hydroxy-3'-methylacetophenone

생성물 1

HCID 21986544Ethyl 2-(4-acetyl-2-methylphenoxy)acetate

시약·촉매·용매 1

HCID 6342Acetonitrile용매

반응 조건

온도
40 °C

실험 절차

1-(4-Hydroxy-3-methylphenyl)ethanone (90 g) and cesium carbonate (216 g) were stirred in acetonitrile (900 ml) at room temperature under nitrogen for 10 minutes. Ethyl bromoacetate (73 ml) was added and the mixture heated to 40° C. for 3 hours. Further ethyl bromoacetate (2.5 ml) and cesium carbonate (1 g) were added and heating continued for a further hour. The cooled reaction was filtered and the filtrate concentrated to give the title compound as a yellow oil.

후처리

  1. temperatureheating
  2. waitcontinued for a further hour
  3. customThe cooled reaction
  4. filtrationwas filtered
  5. concentrationthe filtrate concentrated

출처 및 근거

ORD 기록
ord-5d337718b4324e0dae33ac3f4b6f3bab
출처 데이터셋
uspto-grants-2006_08
특허 번호
US07091237B2

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