4-Chlorophenol → 1-Chloro-4-(2-chloroethoxy)benzene

HRID 962460

반응식

HRID 962460 반응식
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([OH:8])=[CH:4][CH:3]=1.Br[CH2:10][CH2:11][Cl:12].C(=O)([O-])[O-].[K+].[K+]>CC(C)=O>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([O:8][CH2:10][CH2:11][Cl:12])=[CH:4][CH:3]=1

참가 물질

5

반응물 3

HCID 46844-ChlorophenolHCID 78491-Bromo-2-ChloroethaneHCID 11430Potassium Carbonate

생성물 1

HCID 830341-Chloro-4-(2-chloroethoxy)benzene

시약·촉매·용매 1

HCID 180Acetone용매

실험 절차

A mixture of 4-chlorophenol (100 g), 1-bromo-2-chloroethane (335 g), potassium carbonate (129 g) and acetone (2 l) was boiled under reflux with stirring for 18 hours. The mixture was evaporated to dryness under reduced pressure and then dichloromethane was added to the cool residue. The mixture was filtered and the filtrate washed with 5M sodium hydroxide solution, water, dried, filtered and evaporated to give 2-chloroethyl 4-chlorophenyl ether as an oil.

후처리

  1. temperatureunder reflux
  2. customThe mixture was evaporated to dryness under reduced pressure
  3. additiondichloromethane was added to the cool residue
  4. filtrationThe mixture was filtered
  5. washthe filtrate washed with 5M sodium hydroxide solution, water
  6. customdried
  7. filtrationfiltered
  8. customevaporated

출처 및 근거

ORD 기록
ord-aa8d150336f2442bbe8ed61e251865ce
출처 데이터셋
uspto-grants-1998_06
특허 번호
US05760035

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