ethyl N-(2-phenoxyethyl)piperidine-3-carboxylate → N-(2-phenoxyethyl)piperidine-3-carbaldehyde

HRID 962465

반응식

HRID 962465 반응식
[H-].C([Al+]CC(C)C)C(C)C.[O:11]([CH2:18][CH2:19][N:20]1[CH2:25][CH2:24][CH2:23][CH:22]([C:26](OCC)=[O:27])[CH2:21]1)[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1>C1COCC1>[O:11]([CH2:18][CH2:19][N:20]1[CH2:25][CH2:24][CH2:23][CH:22]([CH:26]=[O:27])[CH2:21]1)[C:12]1[CH:13]=[CH:14][CH:15]=[CH:16][CH:17]=1

참가 물질

4

반응물 2

HCID 19085394ethyl N-(2-phenoxyethyl)piperidine-3-carboxylateHCID 21225700Diisobutylaluminumhydride

생성물 1

HCID 19085423N-(2-phenoxyethyl)piperidine-3-carbaldehyde

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

Di-isobutylaluminium hydride (13.2 ml of 1.5M solution in toluene) was added to a mixture of ethyl N-(2-phenoxyethyl)piperidine-3-carboxylate (5.0 g) in dry THF (50 ml) at 0° C. under nitrogen with stirring. The mixture was quenched with water (5 ml) and then treated with saturated Rochelles salt solution. The mixture was stirred at room temperature for 30 minutes and then filtered. The filtrate was separated and the organic layer was washed, dried and evaporated to give N-(2-phenoxyethyl)piperidine-3-carbaldehyde as an oil.

후처리

  1. customThe mixture was quenched with water (5 ml)
  2. additiontreated with saturated Rochelles salt solution
  3. stirringThe mixture was stirred at room temperature for 30 minutes
  4. filtrationfiltered
  5. customThe filtrate was separated
  6. washthe organic layer was washed
  7. customdried
  8. customevaporated

출처 및 근거

ORD 기록
ord-86a32a8d7c7c4ddf816e1c1dd0855d91
출처 데이터셋
uspto-grants-1998_06
특허 번호
US05760035

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