Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
2,4-Hexadienoic Acid → N-[4-(3-Bromoanilino)quinazolin-6-yl]hexa-2,4-dienamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 2,4-Hexadienoic Acid | HCID 5251 | — |
| 반응물 | 4-Methylmorpholine | HCID 7972 | — |
| 반응물 | Isobutyl chloroformate | HCID 62365 | — |
| 반응물 | N4-(3-Bromophenyl)quinazoline-4,6-diamine | HCID 5328042 | — |
| 용매 | Pyridine | HCID 1049 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | N-[4-(3-Bromoanilino)quinazolin-6-yl]hexa-2,4-dienamide | HCID 53794091 | 48.1% |
반응 단계
A solution of 0.67 g of 2,4-hexadienoic acid in 10 ml of tetrahydrofuran was cooled in an ice bath. A 0.79 ml portion of isobutyl chloroformate followed by a 0.66 ml portion of N-methyl morpholine were added. After about 1 minute a solution of 1.6 g of N-(3-bromophenyl)-4,6-quinazolindiamine in 10 ml of pyridine was added. The reaction was allowed to come to room temperature and stir overnight. The solvents were removed at reduced pressure and the solid was recrystallized to give 1.0 g of N-[4-[(3-bromophenyl)amino]-6-quinazolinyl]-2,4-hexadienamide: mp=258°-260° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05760041 |
| 출처 데이터셋 | uspto-grants-1998_06 |
| ORD ID | ord-dd716410943241ecb1fa23f4be07f11b |
| 출처 메모 | uspto-grants-1998_06 |