2,3-Dimethoxyphenol → 3-Benzyl-7,8-dimethoxy-1,2,3,4-tetrahydro-chromeno[3,4-c]pyridin-5-one

반응식

[CH3:1][O:2][C:3]1[C:8]([O:9][CH3:10])=C[CH:6]=[CH:5][C:4]=1O.Cl.[CH2:13]([N:20]1[CH2:25][CH2:24][C:23](=O)[CH:22]([C:27]([O:29][CH3:30])=[O:28])[CH2:21]1)[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1>>[CH2:13]([N:20]1[CH2:25][CH2:24][C:23]2[C:6]3[CH:5]=[CH:4][C:3]([O:2][CH3:1])=[C:8]([O:9][CH3:10])[C:30]=3[O:29][C:27](=[O:28])[C:22]=2[CH2:21]1)[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1

참가 물질

반응물 2

HCID 788282,3-Dimethoxyphenol

HCID 107479Methyl 1-benzyl-4-oxopiperidine-3-carboxylate hydrochloride

생성물 1

HCID 106656263-Benzyl-7,8-dimethoxy-1,2,3,4-tetrahydro-chromeno[3,4-c]pyridin-5-one수율 35%

실험 절차

Prepared by the procedure of Example 1 from 2,3-dimethoxyphenol and methyl 1-benzyl-4-oxo-3-piperidine-carboxylate hydrochloride. Yield 35%; mp 138°-140° C.

출처 및 근거

ORD 기록: ord-652eba3afc2a47e7bbf74cccd53820e9
출처 데이터셋: uspto-grants-1998_06
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US05760050

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