2-(Thiophen-2-yl)propan-2-amine → N-[1-Methyl-1-(2-thienyl)ethyl]-3-cyanoandrosta-3,5-diene-17beta-carboxamide
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[C:1]([C:3]1[CH2:20][CH2:19][C@@:18]2([CH3:21])[C:5](=[CH:6][CH2:7][C@@H:8]3[C@@H:17]2[CH2:16][CH2:15][C@@:13]2([CH3:14])[C@H:9]3[CH2:10][CH2:11][C@@H:12]2[C:22](=[O:30])SC2C=CC=CN=2)[CH:4]=1)#[N:2].[CH3:31][C:32]([NH2:39])([C:34]1[S:35][CH:36]=[CH:37][CH:38]=1)[CH3:33]>>[CH3:31][C:32]([NH:39][C:22]([C@H:12]1[CH2:11][CH2:10][C@H:9]2[C@H:8]3[C@H:17]([CH2:16][CH2:15][C@:13]12[CH3:14])[C@:18]1([CH3:21])[C:5]([CH:4]=[C:3]([C:1]#[N:2])[CH2:20][CH2:19]1)=[CH:6][CH2:7]3)=[O:30])([C:34]1[S:35][CH:36]=[CH:37][CH:38]=1)[CH3:33]참가 물질
3
실험 절차
Following a procedure similar to that described in Example 3(b), but using S-2-pyridyl 3-cyanoandrosta-3,5-diene-17β-thiocarboxylate [prepared as described in Example 3(a)] and 1-methyl-1-(2-thienyl)ethylamine (prepared as described in Preparation 11a) as starting materials, in relative proportions similar to those used in that Example, the title compound was obtained in a yield of 88%.
출처 및 근거
- ORD 기록
- ord-fcdb6bc2bc654fda94127f6587f05c4f
- 출처 데이터셋
- uspto-grants-1998_06
- 특허 번호
- US05760025
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