1-(4-Methoxyphenyl)-1-methylethyl azide → 2-(4-Methoxyphenyl)propan-2-amine

HRID 962700노트

반응식

HRID 962700 반응식
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]([N:12]=[N+]=[N-])([CH3:11])[CH3:10])=[CH:5][CH:4]=1.[H][H]>CO.[Pt]=O>[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]([NH2:12])([CH3:10])[CH3:11])=[CH:5][CH:4]=1

참가 물질

5

반응물 2

HCID 156972291-(4-Methoxyphenyl)-1-methylethyl azideHCID 178418361HCID 178418361, 화합물

생성물 1

HCID 110082782-(4-Methoxyphenyl)propan-2-amine수율 95%

시약·촉매·용매 2

HCID 82844Platinum oxide (PtO)촉매HCID 887Methanol용매

실험 절차

1.58 g of platinum oxide were added to a solution of 21.0 g of 1-(4-methoxyphenyl)-1-methylethyl azide [prepared as described in step (a) above] in 100 ml of methanol. The reaction mixture was then stirred for 5 hours under a stream of hydrogen. At the end of this time, the mixture was filtered, diluted with methylene chloride, and washed with an aqueous solution of sodium hydrogencarbonate, with water and with a saturated aqueous solution of sodium chloride, in that order. It was then dried over anhydrous magnesium sulfate, and concentrated by evaporation under reduced pressure, to give 17.2 g (yield 95%) of the title compound.

후처리

  1. filtrationAt the end of this time, the mixture was filtered
  2. additiondiluted with methylene chloride
  3. washwashed with an aqueous solution of sodium hydrogencarbonate, with water and with a saturated aqueous solution of sodium chloride, in that order
  4. dry with materialIt was then dried over anhydrous magnesium sulfate
  5. concentrationconcentrated by evaporation under reduced pressure

출처 및 근거

ORD 기록
ord-0b5c254a87af49df82427339d98508b1
출처 데이터셋
uspto-grants-1998_06
특허 번호
US05760025

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