Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Hydrochloric Acid → 6-Methyl-2-(trifluoroacetyl)tetralone
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Hydrochloric Acid | HCID 313 | — |
| 반응물 | Ethyl trifluoroacetate | HCID 9794 | — |
| 반응물 | 3,4-dihydro-6-methylnaphthalen-1(2H)-one | HCID 162620 | — |
| 반응물 | Sodium Methoxide | HCID 10942334 | — |
| 용매 | Diethyl Ether | HCID 3283 | — |
| 생성물 | 6-Methyl-2-(trifluoroacetyl)tetralone | HCID 22315552 | 85.1% |
반응 단계
Ethyl trifluoroacetate (5.33 g, 37.5 mmol) was dissolved in ether (50 mL) and treated with a sodium methoxide solution (25% in methanol, 9.92 g, 45.9 mmol) followed by 6-methyltetralone (5.94 g, 37.1 mmol). The reaction was stirred at room temperature for 6.1 hours then treated with 1N HCl (20 mL). The organic layer was collected, washed with brine, dried over MgSO4, and concentrated in vacuo to give a brown oil (8.09 g) that was used in the next step without further purification.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05760068 |
| 출처 데이터셋 | uspto-grants-1998_06 |
| ORD ID | ord-7467b15f939f49fbbe0d9b836de2ac2e |
| 출처 메모 | uspto-grants-1998_06 |