Methanol → HCID 19027583, 화합물

HRID 962911노트

반응식

HRID 962911 반응식
[C:1]1([C:7]2[N:11]=[C:10]([CH2:12][CH2:13][C:14](O)=[O:15])[O:9][N:8]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.CO>O1CCCC1>[C:1]1([C:7]2[N:11]=[C:10]([CH2:12][CH2:13][CH2:14][OH:15])[O:9][N:8]=2)[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

참가 물질

4

반응물 2

HCID 887MethanolHCID 6659683-(3-phenyl-1,2,4-oxadiazol-5-yl)propanoic acid

생성물 1

HCID 19027583HCID 19027583, 화합물수율 56.3%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매2회

실험 절차

A solution of 2.5 ml of borane-methyl sulfide complex in 2M solution in tetrahydrofuran, 920 mg of 3-(3-phenyl-1,2,4-oxadiazol 5-yl)-propanoic acid (prepared by SRIRASTAVA et al., J. Heterocycl. Chem., Vol. 21, p. 1193 (1984) and 20 ml of tetrahydrofuran was stirred for one hour at ambient temperature. 10 ml of methanol were added over 5 minutes and evaporation to dryness under reduced pressure was carried out. The residue was chromatographed on silica (eluant: ethyl acetate-hexane (6-4)) to obtain 485 mg of the expected product.

후처리

  1. customevaporation to dryness under reduced pressure
  2. customThe residue was chromatographed on silica (eluant: ethyl acetate-hexane (6-4))

출처 및 근거

ORD 기록
ord-9e86aef9cc4b4e21be7b918793345ff7
출처 데이터셋
uspto-grants-1998_06
특허 번호
US05760233

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