Ethyl bromoacetate → HCID 21986425, 화합물

HRID 9630노트

반응식

HRID 9630 반응식
[OH:1][CH2:2][C:3]1[CH:8]=[C:7]([CH3:9])[C:6]([OH:10])=[C:5]([CH3:11])[CH:4]=1.Br[CH2:13][C:14]([O:16][CH2:17][CH3:18])=[O:15].C(=O)([O-])[O-].[Cs+].[Cs+]>C(#N)C>[CH2:17]([O:16][C:14](=[O:15])[CH2:13][O:10][C:6]1[C:5]([CH3:11])=[CH:4][C:3]([CH2:2][OH:1])=[CH:8][C:7]=1[CH3:9])[CH3:18]

참가 물질

5

반응물 3

HCID 7748Ethyl bromoacetateHCID 10796Cesium carbonateHCID 2786604-(hydroxymethyl)-2,6-dimethylphenol

생성물 1

HCID 21986425HCID 21986425, 화합물

시약·촉매·용매 1

HCID 6342Acetonitrile용매

실험 절차

A solution of 4-(hydroxymethyl)-2,6-dimethylphenol (P. Claus et al., Monatsh. Chem. 1972, 103(4), 1178–1193) (1.9 g) in acetonitrile (50 ml) was treated with ethyl bromoacetate (2.17 g) and caesium carbonate (4.24 g) and the mixture stirred at room temperature overnight. The solution was concentrated and the residue partitioned between ethyl acetate and water. The organic layer was collected, dried over magnesium sulfate and filtered. The filtrate was concentrated to give the title compound as a yellow oil.

후처리

  1. concentrationThe solution was concentrated
  2. customthe residue partitioned between ethyl acetate and water
  3. customThe organic layer was collected
  4. dry with materialdried over magnesium sulfate
  5. filtrationfiltered
  6. concentrationThe filtrate was concentrated

출처 및 근거

ORD 기록
ord-42f38fc69f714700a45eeb1a3594703c
출처 데이터셋
uspto-grants-2006_08
특허 번호
US07091237B2

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