Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 963055생성일: 2026년 10월 26일
Sulfuric Acid → Ethyl 2-(3-bromo-4-(3-(2-chlorobenzoyl)-5-ethylthiophen-2-yl) [1,2,4]triazol-5-ylmethylcarbamoyl)indole-1-acetate
https://huagongshe.com/reaction/963055
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Sulfuric Acid | HCID 1118 | — |
| 반응물 | Sodium Bicarbonate | HCID 516892 | — |
| 반응물 | 1-Ethoxycarbonylmethylindole-2-carbonyl chloride | HCID 19085163 | — |
| 반응물 | 9-Bromo-4-(2-chlorophenyl)-2-ethyl-6H-thieno[3,2-f] [1,2,4]triazolo[4,3-a] [1,4]diazepine | HCID 67727685 | — |
| 용매 | Chloroform | HCID 6212 | — |
| 생성물 | Ethyl 2-(3-bromo-4-(3-(2-chlorobenzoyl)-5-ethylthiophen-2-yl) [1,2,4]triazol-5-ylmethylcarbamoyl)indole-1-acetate | HCID 67727711 | — |
반응 단계
9-Bromo-4-(2-chlorophenyl)-2-ethyl-6H-thieno[3,2-f] [1,2,4]triazolo[4,3-a] [1,4]diazepine is added to 2M sulfuric acid, and the mixture is stirred at 80° C. overnight. Sodium hydrogencarbonate is added to the reaction mixture to make the mixture alkaline. Chloroform and 1-ethoxycarbonylmethylindole-2-carbonyl chloride are added, and the mixture is stirred at room temperature for 2 hours to give ethyl 2-(3-bromo-4-(3-(2-chlorobenzoyl)-5-ethylthiophen-2-yl) [1,2,4]triazol-5-ylmethylcarbamoyl)indole-1-acetate.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US05760032 |
|---|
| 출처 데이터셋 | uspto-grants-1998_06 |
|---|
| ORD ID | ord-af9f8ca814e94e85a28d22b03ef4b8ea |
|---|
| 출처 메모 | uspto-grants-1998_06 |
|---|
