참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Dimethylformamide | HCID 6228 | — |
| 반응물 | Lithium Carbonate | HCID 11125 | — |
| 반응물 | Ethanethiol, 2-(diethylamino)-, hydrochloride (1:1) | HCID 16031 | — |
| 반응물 | 10-chloro-8-hydroxy-11H-indeno[1,2-b]quinolin-11-one | HCID 19081815 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | HCID 22440208 | HCID 22440208 | 63.2% |
반응 단계
A mixture of 400 mg (1.4 mmol) of 10-chloro-8-hydroxy-11H-indeno[1,2-b]quinolin-11-one, 629 mg (8.5 mmol) of lithium carbonate, 963 mg (5.7 mmol) of 2-diethylaminoethanethiol hydrochloride and 8 ml of N,N-dimethylformamide was stirred for 5 hours with heating at 90° C. After completion of the reaction, the reaction mixture was added to water, and precipitated crystals were collected by filteration. The crystals were recrystallized from ethanol, giving 310 mg of the title compound (yield: 57.7%). The property values are shown in Table 1.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US05763453 |
|---|
| 출처 데이터셋 | uspto-grants-1998_06 |
|---|
| ORD ID | ord-f77d3e454a19410ba31af60dc53a8981 |
|---|
| 출처 메모 | uspto-grants-1998_06 |
|---|
