Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 963331생성일: 2026년 10월 25일
5-Bromosalicylaldehyde → Methanone, (5-bromo-2-benzofuranyl)(5-methyl-2-phenyl-4-oxazolyl)-
https://huagongshe.com/reaction/963331
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | 5-Bromosalicylaldehyde | HCID 72863 | — |
| 반응물 | Sodium Methoxide | HCID 10942334 | — |
| 반응물 | 2-Bromo-1-(5-methyl-2-phenyl-1,3-oxazol-4-yl)ethan-1-one | HCID 14913650 | — |
| 용매 | Ethanol | HCID 702 | — |
| 생성물 | Methanone, (5-bromo-2-benzofuranyl)(5-methyl-2-phenyl-4-oxazolyl)- | HCID 10500081 | — |
반응 단계
To a slurry of 294 g of 5-bromosalicylaldehyde in 3 liters of dry ethanol was added 79.06 g of sodium methoxide and the mixture allowed to stir for 20 minutes. To the resulting yellow slurry was added 410 g of 2-phenyl-4-bromoacetyl-5-methyloxazole and the slurry heated to 780° C. for 2 hours. An additional 250 mg of sodium methoxide was added and heating continued overnight under a nitrogen atmosphere. The reaction was cooled and the solids filtered and washed with ethanol, 393 g, mp 212°-213° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 특허 번호 | US05763467 |
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| 출처 데이터셋 | uspto-grants-1998_06 |
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| ORD ID | ord-e6494d0301f6494d96d173641848b4df |
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| 출처 메모 | uspto-grants-1998_06 |
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