3,5-Dimethoxybenzyl chloride → 1-[4-Acetylamino-5-bromo-2-(3,5-dimethoxybenzyloxy)phenyl]-5-bromopentan-1-one

HRID 963342

반응식

HRID 963342 반응식
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:8]=[C:9]([O:11][CH3:12])[CH:10]=1)[CH2:6]Cl.C(NC1C(Cl)=CC(C(=O)CCCCCl)=C(O)C=1)(=O)C.[C:32]([NH:35][C:36]1[C:41]([Br:42])=[CH:40][C:39]([C:43](=[O:49])[CH2:44][CH2:45][CH2:46][CH2:47][Br:48])=[C:38]([OH:50])[CH:37]=1)(=[O:34])[CH3:33]>>[C:32]([NH:35][C:36]1[C:41]([Br:42])=[CH:40][C:39]([C:43](=[O:49])[CH2:44][CH2:45][CH2:46][CH2:47][Br:48])=[C:38]([O:50][CH2:6][C:5]2[CH:4]=[C:3]([O:2][CH3:1])[CH:10]=[C:9]([O:11][CH3:12])[CH:8]=2)[CH:37]=1)(=[O:34])[CH3:33]

참가 물질

4

반응물 3

HCID 27583953,5-Dimethoxybenzyl chlorideHCID 190818791-(4-Acetylamino-5-chloro-2-hydroxyphenyl)-5-chloropentan-1-oneHCID 190819521-(4-Acetylamino-5-bromo-2-hydroxyphenyl)-5-bromopentan-1-one

생성물 1

HCID 190819551-[4-Acetylamino-5-bromo-2-(3,5-dimethoxybenzyloxy)phenyl]-5-bromopentan-1-one

실험 절차

Proceeding as in Example 4, Step (b), but replacing iodomethane with 3,5-dimethoxybenzylchloride and 1-(4-acetylamino-5-chloro-2-hydroxyphenyl)-5-chloropentan-1-one with 1-(4-acetylamino-5-bromo-2-hydroxyphenyl)-5-bromo-pentan-1-one, gave 1-[4-acetylamino-5-bromo-2-(3,5-dimethoxybenzyloxy)phenyl]-5-bromopentan-1-one.

출처 및 근거

ORD 기록
ord-5554108108704e048f88d79e8c2a69f2
출처 데이터셋
uspto-grants-1998_06
특허 번호
US05763458

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