참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Water | HCID 962 | — |
| 반응물 | Sodium Iodide | HCID 5238 | — |
| 반응물 | Piperidine | HCID 8082 | — |
| 반응물 | 1-(4-Acetylamino-5-chloro-2-methoxyphenyl)-5-chloropentan-1-one | HCID 19081861 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | 1-(4-Acetylamino-5-chloro-2-methoxyphenyl)-5-(piperidin-1-yl)pentan-1-one | HCID 19081933 | 96.5% |
반응 단계
1-(4-Acetylamino-5-chloro-2-methoxyphenyl)-5-chloropentan-1-one (0.72 g, 2.26 mmol), sodium iodide (0.15 g, 0.1 mmol), and piperidine (1.72 g, 20 mmol) were combined in DMF (8.0 mL) and the mixture was heated to 80° C. for 4.5 hours. Water was then added to form a precipitate. Filtration gave 1-(4-acetylamino-5-chloro-2-methoxyphenyl)-5-(piperidin-1-yl)pentan-1-one (0.8 g, 2.18 mmol), m.p. 74°-75° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US05763458 |
|---|
| 출처 데이터셋 | uspto-grants-1998_06 |
|---|
| ORD ID | ord-961cf621db1c4e61b496032ab17b2b88 |
|---|
| 출처 메모 | uspto-grants-1998_06 |
|---|
