Piperidine → 1-[4-Amino-5-chloro-2-(3,5-dimethoxybenzyloxy)-phenyl]-5-[4-(prop-1-yl)piperidin-1-yl]pentan-1-one
반응식
C([NH:4][C:5]1[C:10]([Cl:11])=[CH:9][C:8]([C:12](=[O:18])[CH2:13][CH2:14][CH2:15][CH2:16]Cl)=[C:7]([O:19][CH2:20][C:21]2[CH:26]=[C:25]([O:27][CH3:28])[CH:24]=[C:23]([O:29][CH3:30])[CH:22]=2)[CH:6]=1)(=O)C.N1CCCCC1.[CH2:37]([CH:40]1[CH2:45][CH2:44][NH:43][CH2:42][CH2:41]1)[CH2:38][CH3:39]>>[NH2:4][C:5]1[C:10]([Cl:11])=[CH:9][C:8]([C:12](=[O:18])[CH2:13][CH2:14][CH2:15][CH2:16][N:43]2[CH2:44][CH2:45][CH:40]([CH2:37][CH2:38][CH3:39])[CH2:41][CH2:42]2)=[C:7]([O:19][CH2:20][C:21]2[CH:26]=[C:25]([O:27][CH3:28])[CH:24]=[C:23]([O:29][CH3:30])[CH:22]=2)[CH:6]=1참가 물질
4
실험 절차
Proceeding as in Example 4, Step (c), but replacing 1-(4-acetylamino-5-chloro-2-methoxyphenyl)-5-chloropentan-1-one with 1-[4-acetylamino-5-chloro-2-(3,5-dimethoxybenzyloxy)phenyl]-5-chloropentan-1-one and piperidine with 4-(prop-1-yl)piperidine, gave 1-[4-amino-5-chloro-2-(3,5-dimethoxybenzyloxy)-phenyl]-5-[4-(prop-1-yl)piperidin-1-yl]pentan-1-one, m.p. 119-120° C.