반응식
[NH2:1][C:2]1[C:7]([Cl:8])=[CH:6][C:5]([C:9](=[O:20])[CH2:10][CH2:11][CH2:12][CH2:13][N:14]2[CH2:19][CH2:18][CH2:17][CH2:16][CH2:15]2)=[C:4]([O:21][CH3:22])[CH:3]=1.[CH3:23][C:24]1[CH:25]=[C:26]([CH:29]=[C:30]([CH3:32])[CH:31]=1)CCl>>[ClH:8].[NH2:1][C:2]1[C:7]([Cl:8])=[CH:6][C:5]([C:9](=[O:20])[CH2:10][CH2:11][CH2:12][CH2:13][N:14]2[CH2:15][CH2:16][CH2:17][CH2:18][CH2:19]2)=[C:4]([O:21][CH2:22][C:26]2[CH:29]=[C:30]([CH3:32])[CH:31]=[C:24]([CH3:23])[CH:25]=2)[CH:3]=1참가 물질
3
실험 절차
Proceeding as in Example 12, Step (a), but replacing 1-(4-amino-5-chloro-2-methoxyphenyl)-3-{1-[2-(methylsulfonyl)aminoethyl]piperidin-4-ylpropan-1-one with 1-[4-amino-5-chloro-2-methoxyphenyl]-5-(piperidin-1-yl)pentan-1-one, and then as in Example 12, Step (b), but replacing 3,5-dimethoxybenzyl chloride with 3,5-dimethylbenzyl chloride, gave 1-[4-amino-5-chloro-2-(3,5-dimethylbenzyloxy)-phenyl]-5-(piperidin-1-yl)pentan-1-one hydrochloride, m.p. 218°-233° C.
출처 및 근거
- ORD 기록
- ord-0ea2869f10b2413c86aeb4f10f31f03f
- 출처 데이터셋
- uspto-grants-1998_06
- 특허 번호
- US05763458
연결된 노트
불러오는 중…