Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
5-Iodosalicylic acid → N-cyclopropyl-2-hydroxy-5-iodo-benzamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 5-Iodosalicylic acid | HCID 8388 | — |
| 반응물 | Carbon tetrabromide | HCID 11205 | — |
| 반응물 | Triphenylphosphine | HCID 11776 | — |
| 반응물 | Cyclopropylamine | HCID 69828 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | N-cyclopropyl-2-hydroxy-5-iodo-benzamide | HCID 19081760 | 18.1% |
반응 단계
13bh) A mixture of 2.64 g of 2-hydroxy-5-iodo-benzoic acid, 0.69 g of cyclopropylamine and 3.65 g of carbon tetrabromide in 40 ml of methylene chloride is treated portionwise at room temperature with 2.62 g of triphenylphosphine. After 2 hrs. the mixture is filtered and the filtrate is concentrated. Chromatography on silica gel with ethyl acetate/cyclohexane 1:4 gives 550 mg of crude N-cyclopropyl-2-hydroxy-5-iodo-benzamide. Yield: 18%.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05763450 |
| 출처 데이터셋 | uspto-grants-1998_06 |
| ORD ID | ord-306d3aab035e4e08a8f3d9d6b64efce8 |
| 출처 메모 | uspto-grants-1998_06 |