N-tert-Butoxycarbonyl-L-tryptophan → (3S)-3-amino-1-{(3-azabicyclo[3.2.2]non-3-yl)carbonylmethyl}-2,3-dihydro-5-(2-fluorophenyl)-1H-1,4-benzodiazepin-2-one

HRID 963465

반응식

HRID 963465 반응식
C(OC(N[C@H](C(O)=O)CC1C2C(=CC=CC=2)NC=1)=O)(C)(C)C.[NH2:23][CH:24]1[N:30]=[C:29]([C:31]2[CH:36]=[CH:35][CH:34]=[CH:33][C:32]=2[F:37])[C:28]2[CH:38]=[CH:39][CH:40]=[CH:41][C:27]=2[N:26]([CH2:42][C:43]([N:45]2[CH2:51][CH:50]3[CH2:52][CH2:53][CH:47]([CH2:48][CH2:49]3)[CH2:46]2)=[O:44])[C:25]1=[O:54]>C(#N)C.C(Cl)Cl>[NH2:23][C@H:24]1[N:30]=[C:29]([C:31]2[CH:36]=[CH:35][CH:34]=[CH:33][C:32]=2[F:37])[C:28]2[CH:38]=[CH:39][CH:40]=[CH:41][C:27]=2[N:26]([CH2:42][C:43]([N:45]2[CH2:51][CH:50]3[CH2:52][CH2:53][CH:47]([CH2:48][CH2:49]3)[CH2:46]2)=[O:44])[C:25]1=[O:54]

참가 물질

5

반응물 2

HCID 83169N-tert-Butoxycarbonyl-L-tryptophanHCID 19081160(3RS)-1-{(3-azabicyclo[3.2.2]non-3-yl)-carbonylmethyl}-3-amino-5-(2-fluorophenyl)-2,3-dihydro-1H-1,4-benzodiazepin-2-one

생성물 1

HCID 54425021(3S)-3-amino-1-{(3-azabicyclo[3.2.2]non-3-yl)carbonylmethyl}-2,3-dihydro-5-(2-fluorophenyl)-1H-1,4-benzodiazepin-2-one수율 46%

시약·촉매·용매 2

HCID 6342Acetonitrile용매HCID 6344Dichloromethane용매

실험 절차

To a solution of N-tert-butoxycarbonyl-L-tryptophan (0.70 g) in acetonitrile (20 ml) was added dropwise a solution of (3RS)-3-amino-1-{(3-azabicyclo[3.2.2]non-3-yl)carbonylmethyl}-2,3-dihydro-5-(2-fluorophenyl)-1H-1,4-benzodiazepin-2-one (1.00 g) in methylene chloride (5 ml) under stirring at ambient temperature. The mixture was stirred overnight. The precipitate was collected by filtration and the colorless solid was partitioned between methylene chloride and 0.5N NaOH. The organic layer was dried over sodium sulfate, filtered and concentrated in vacuo to afford (3S)-3-amino-1-{(3-azabicyclo[3.2.2]non-3-yl)carbonylmethyl}-2,3-dihydro-5-(2-fluorophenyl)-1H-1,4-benzodiazepin-2-one (0.46 g) as s colorless crystal.

후처리

  1. stirringThe mixture was stirred overnight
  2. filtrationThe precipitate was collected by filtration
  3. customthe colorless solid was partitioned between methylene chloride and 0.5N NaOH
  4. dry with materialThe organic layer was dried over sodium sulfate
  5. filtrationfiltered
  6. concentrationconcentrated in vacuo

출처 및 근거

ORD 기록
ord-b138eac3035940ed844fdebad43ac9a4
출처 데이터셋
uspto-grants-1998_06
특허 번호
US05763437

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