참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Hydrochloric Acid | HCID 313 | — |
| 반응물 | Triethylamine hydrochloride | HCID 11130 | — |
| 반응물 | 3-Nitrobenzonitrile | HCID 12079 | — |
| 반응물 | Sodium Azide | HCID 33557 | — |
| 용매 | N-methyl-2-pyrrolidone | HCID 13387 | — |
| 생성물 | 5-(3-nitrophenyl)tetrazole | HCID 285129 | 93.1% |
반응 단계
A mixture of 3-nitrobenzonitrile (3.70 g, 25 mmol), sodium azide (4.88 g, 75 mmol) and triethylamine hydrochloride (10.32 g, 75 mniol) in N-methylpyrrolidone (55 ml) was heated at 130° C. for 2 hours under stirring. The reaction mixture was poured into ice-water, to which was dropwise added 6N hydrochloric acid in order to acidify. The resultant precipitates were collected by filtration, washed with water and dried to afford 5-(3-nitrophenyl)-1H-tetrazole (4.45 g, 93.1%), which was used in a following reaction without further purification.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US05763437 |
|---|
| 출처 데이터셋 | uspto-grants-1998_06 |
|---|
| ORD ID | ord-b4977d2e8dce40dd8945e276bc302e29 |
|---|
| 출처 메모 | uspto-grants-1998_06 |
|---|
