Aluminium lithium hydride → 1-(4-Ethoxyphenyl)-1-(2-fluoro-3-hydroxyprop-1-enyl)cyclopropane

HRID 963810노트

반응식

HRID 963810 반응식
[CH2:1]([O:3][C:4]1[CH:9]=[CH:8][C:7]([C:10]2([CH:13]=[C:14]([F:19])[C:15](OC)=[O:16])[CH2:12][CH2:11]2)=[CH:6][CH:5]=1)[CH3:2].[H-].[Al+3].[Li+].[H-].[H-].[H-]>C(OCC)C>[CH2:1]([O:3][C:4]1[CH:9]=[CH:8][C:7]([C:10]2([CH:13]=[C:14]([F:19])[CH2:15][OH:16])[CH2:12][CH2:11]2)=[CH:6][CH:5]=1)[CH3:2]

참가 물질

4

반응물 2

HCID 21226445Aluminium lithium hydrideHCID 542883691-(4-Ethoxyphenyl)-1-(2-fluoro-2-(methoxycarbonyl)ethenyl)cyclopropane

생성물 1

HCID 542015341-(4-Ethoxyphenyl)-1-(2-fluoro-3-hydroxyprop-1-enyl)cyclopropane수율 74%

시약·촉매·용매 1

HCID 3283Diethyl Ether용매

실험 절차

The method of Example 9 was repeated using 1-(4-ethoxyphenyl)-1-(2-fluoro-2-(methoxycarbonyl)ethenyl)-cyclopropane (Example 2) (2.3 g), diethyl ether (20 ml) and lithium aluminium hydride (0.55 g) to yield the title compound (1.51 g, 74%).

출처 및 근거

ORD 기록
ord-9747fbd770df4763a64f6afccfa66214
출처 데이터셋
uspto-grants-1998_06
특허 번호
US05763700

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