Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Triethylamine → Tert-butyl 1-(aminoimino-methyl)-piperidin-4-ylmethylcarbamate hemisulfite
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Triethylamine | HCID 8471 | — |
| 반응물 | Tert-butyl (piperidin-4-ylmethyl)carbamate | HCID 723429 | — |
| 반응물 | Methanesulfonic acid, aminoimino- | HCID 9877361 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | Tert-butyl 1-(aminoimino-methyl)-piperidin-4-ylmethylcarbamate hemisulfite | HCID 131720709 | — |
반응 단계
A solution of 130 g of 1,1-dimethylethyl (4piperidinylmethyl)-carbamate in 1300 ml of DMF is treated with 138 ml of triethylamine and 61.8 g of formamidinesulfonic acid and the mixture is stirred at room temperature overnight. The precipitated material is filtered, suspended in 500 ml of ethanol, again filtered off and dried. There are obtained 65.6 g of tert-butyl 1-(aminoimino-methyl)-piperidin-4-ylmethylcarbamate hemisulfite, MS (ISP): 257.4 (M+H)+.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05763604 |
| 출처 데이터셋 | uspto-grants-1998_06 |
| ORD ID | ord-86e6069001dc41e4af4476953984ac18 |
| 출처 메모 | uspto-grants-1998_06 |