Water → HCID 9929845, 화합물

HRID 963922노트

반응식

HRID 963922 반응식
[CH2:1]([NH2:3])[CH3:2].[CH3:4][C:5]1[C:6]([S:19][C:20]2[CH:28]=[CH:27][C:23]([C:24](Cl)=[O:25])=[CH:22][CH:21]=2)=[CH:7][C:8]2[C:9]([CH3:18])([CH3:17])[CH2:10][CH2:11][C:12]([CH3:16])([CH3:15])[C:13]=2[CH:14]=1.O>C1COCC1>[CH2:1]([NH:3][C:24](=[O:25])[C:23]1[CH:22]=[CH:21][C:20]([S:19][C:6]2[C:5]([CH3:4])=[CH:14][C:13]3[C:12]([CH3:15])([CH3:16])[CH2:11][CH2:10][C:9]([CH3:18])([CH3:17])[C:8]=3[CH:7]=2)=[CH:28][CH:27]=1)[CH3:2]

참가 물질

5

반응물 3

HCID 962WaterHCID 6341EthylamineHCID 22117430HCID 22117430, 화합물

생성물 1

HCID 9929845HCID 9929845, 화합물

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매2회

실험 절차

640 μl (8 mmol) of a 70% solution of ethylamine and 20 ml of THF were introduced into a round-bottomed flask. A solution of 735 mg (2 mmol) of 4-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydro-2-naphthylthio)benzoyl chloride dissolved in 30 ml of THF was added dropwise and the mixture was stirred at room temperature for three hours. The reaction medium was poured into water, extracted with ethyl acetate, the organic phase decanted off, dried over magnesium sulfate and evaporated.

후처리

  1. additionwas added dropwise
  2. extractionextracted with ethyl acetate
  3. customthe organic phase decanted off
  4. dry with materialdried over magnesium sulfate
  5. customevaporated

출처 및 근거

ORD 기록
ord-3dfaf3558209491f9d6e28477b10a9f2
출처 데이터셋
uspto-grants-1998_06
특허 번호
US05766610

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