1,1-Diphenylbutane-1,4-diol → 4,4-Diphenylbutan-1-ol

HRID 963978노트

반응식

HRID 963978 반응식
[C:1]1([C:7]([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)(O)[CH2:8][CH2:9][CH2:10][OH:11])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1>CO.[Pd]>[C:13]1([CH:7]([C:1]2[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=2)[CH2:8][CH2:9][CH2:10][OH:11])[CH:14]=[CH:15][CH:16]=[CH:17][CH:18]=1

참가 물질

4

반응물 1

HCID 966791,1-Diphenylbutane-1,4-diol

생성물 1

HCID 925194,4-Diphenylbutan-1-ol수율 91%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 887Methanol용매

실험 절차

1,1-Diphenyl-1,4-butanediol (26.62 g, 0.110 mol) was dissolved in MeOH and shaken with 20% Pd/C (1.50 g) on a Parr apparatus under an H2 atmosphere (50 psi) for 17 hours. The MeOH was removed in vacuo, and the residue chromatographed on silica gel eluting with 35% EtOAc/Hexanes gave 22.53 g (91%) of desired product.

후처리

  1. customThe MeOH was removed in vacuo
  2. customthe residue chromatographed on silica gel eluting with 35% EtOAc/Hexanes

출처 및 근거

ORD 기록
ord-bddfb8fb4083420fb48abe2792373864
출처 데이터셋
uspto-grants-1998_06
특허 번호
US05767129

반응 노트

불러오는 중…