Ethyl Acetate → 2-(4,4-Diphenylbutyl)-5-hydroxyisoquinolinium bromide

HRID 963980노트

반응식

HRID 963980 반응식
[OH:1][C:2]1[CH:11]=[CH:10][CH:9]=[C:8]2[C:3]=1[CH:4]=[CH:5][N:6]=[CH:7]2.[Br:12][CH2:13][CH2:14][CH2:15][CH:16]([C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1)[C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1.C(OCC)(=O)C>CN(C=O)C>[Br-:12].[C:17]1([CH:16]([C:23]2[CH:24]=[CH:25][CH:26]=[CH:27][CH:28]=2)[CH2:15][CH2:14][CH2:13][N+:6]2[CH:5]=[CH:4][C:3]3[C:8](=[CH:9][CH:10]=[CH:11][C:2]=3[OH:1])[CH:7]=2)[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1

참가 물질

5

반응물 3

HCID 8857Ethyl AcetateHCID 30386Isoquinolin-5-olHCID 122234581,1-Diphenyl-4-bromobutane

생성물 1

HCID 158708932-(4,4-Diphenylbutyl)-5-hydroxyisoquinolinium bromide수율 69.6%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

반응 조건

온도
80 °C

실험 절차

A mixture of 5-hydroxyisoquinoline (2.17 g, 14.95 mmol) and 1-bromo-4,4-diphenylbutane (4.79 g, 16.56 mmol) in 75 mL of anhydrous DMF was stirred at 80° C. for 16 hours. The reaction mixture was cooled to room temperature. Ethyl acetate (200 mL) was added to precipitate product. The solid was collected by filtration and washed with ethyl acetate (1×70 mL). The solid was air-dried to give 4.52 g of product as an off-white solid.

후처리

  1. temperatureThe reaction mixture was cooled to room temperature
  2. customto precipitate product
  3. filtrationThe solid was collected by filtration
  4. washwashed with ethyl acetate (1×70 mL)
  5. customThe solid was air-dried

출처 및 근거

ORD 기록
ord-cdcbb52ef3a04fea8042aa5de75d6e0d
출처 데이터셋
uspto-grants-1998_06
특허 번호
US05767129

반응 노트

불러오는 중…