4-Carbamoyl-1-phenylpyridinium chloride → 1-Phenylpiperidine-4-carboxamide

HRID 963998노트

반응식

HRID 963998 반응식
[Cl-].[C:2]([C:5]1[CH:10]=[CH:9][N+:8]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)=[CH:7][CH:6]=1)(=[O:4])[NH2:3]>[Pd].C(O)C>[C:11]1([N:8]2[CH2:9][CH2:10][CH:5]([C:2]([NH2:3])=[O:4])[CH2:6][CH2:7]2)[CH:12]=[CH:13][CH:14]=[CH:15][CH:16]=1

참가 물질

4

반응물 1

HCID 107048844-Carbamoyl-1-phenylpyridinium chloride

생성물 1

HCID 105843391-Phenylpiperidine-4-carboxamide수율 52.9%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 702Ethanol용매

실험 절차

A mixture of 4-carbamoyl-1-phenylpyridinium chloride (13 g), 10% palladium-on-carbon catalyst (260 mg) and ethanol (250 ml) was hydrogenated at ambient temperature and pressure for 2 days. The solution was filtered (Celite) and the filtrate was concentrated to approximately 50 ml. This solution was cooled and the solid precipitate collected by filtration to give 1-phenylpiperidine-4-carboxamide (5.99 g).

후처리

  1. customwas hydrogenated at ambient temperature
  2. filtrationThe solution was filtered (Celite)
  3. concentrationthe filtrate was concentrated to approximately 50 ml
  4. temperatureThis solution was cooled
  5. filtrationthe solid precipitate collected by filtration

출처 및 근거

ORD 기록
ord-a11b4d6683ae48778c67323737e82d03
출처 데이터셋
uspto-grants-1998_06
특허 번호
US05767116

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