4-Carbamoyl-1-(2,4-dinitrophenyl)pyridinium chloride → HCID 10540454, 화합물

HRID 964011노트

반응식

HRID 964011 반응식
[O:1]1[CH2:5][CH2:4][C:3]2[CH:6]=[CH:7][CH:8]=[C:9]([NH2:10])[C:2]1=2.[Cl-:11].[C:12]([C:15]1[CH:20]=[CH:19][N+](C2C=CC([N+]([O-])=O)=CC=2[N+]([O-])=O)=[CH:17][CH:16]=1)(=[O:14])[NH2:13]>CO>[Cl-:11].[O:1]1[CH2:5][CH2:4][C:3]2[CH:6]=[CH:7][CH:8]=[C:9]([N+:10]3[CH:19]=[CH:20][C:15]([C:12](=[O:14])[NH2:13])=[CH:16][CH:17]=3)[C:2]1=2

참가 물질

4

반응물 2

HCID 106160034-Carbamoyl-1-(2,4-dinitrophenyl)pyridinium chlorideHCID 128059502,3-Dihydro-1-benzofuran-7-amine

생성물 1

HCID 10540454HCID 10540454, 화합물

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

A mixture of 2,3-dihydrobenzo[b]furan-7-ylamine (6.8 g prepared in a similar manner to that described in Tetrahedron Letters 1982,23,147), 4-carbamoyl-1-(2,4-dinitrophenyl)pyridinium chloride (14.7 g prepared in a similar manner to that described in Example 2) and methanol (400 ml) was stirred under reflux for 5 hours then allowed to stand at ambient temperature and heated for 16 hours. The solvent was removed in vacuo, and the residue was triturated with hot acetone, cooled and filtered to give 1-(2,3-dihydrobenzo[b]furan-7-yl)-4-carbamoylpyridinium chloride as a yellow solid (11.5 g), m.p. 289°-290° C.

후처리

  1. customprepared in a similar manner to that
  2. customprepared in a similar manner to that
  3. temperatureunder reflux for 5 hours
  4. customto stand at ambient temperature
  5. temperatureheated for 16 hours
  6. customThe solvent was removed in vacuo
  7. customthe residue was triturated with hot acetone
  8. temperaturecooled
  9. filtrationfiltered

출처 및 근거

ORD 기록
ord-0fc4e65ccaaa485c857668d0d2669af8
출처 데이터셋
uspto-grants-1998_06
특허 번호
US05767116

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