HCID 86750087, 화합물 → (+)-cis-4-Amino-1-benzyl-3-methyl-2-oxopyrrolidine
반응식
[CH2:1]([N:8]1[CH2:12][C@H:11]([NH:13]C(OC(C)(C)C)=O)[C@H:10]([CH3:21])[C:9]1=[O:22])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1>FC(F)(F)C(O)=O>[NH2:13][C@H:11]1[CH2:12][N:8]([CH2:1][C:2]2[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=2)[C:9](=[O:22])[C@H:10]1[CH3:21]참가 물질
3
실험 절차
In 15 ml of trifluoroacetic acid was dissolved 1.76 g of Compound (44). After 1 hour, the solution was concentrated under reduced pressure. To the residue was added 100 ml of water, and the mixture was washed with benzene. The aqueous layer was adjusted to a pH of 12 with sodium hydroxide and extracted with chloroform. The organic layer was dried over anhydrous sodium sulfate, and the solvent was evaporated to obtain the titled compound (45) as a colorless oil.
후처리
- concentrationthe solution was concentrated under reduced pressure
- additionTo the residue was added 100 ml of water
- washthe mixture was washed with benzene
- extractionextracted with chloroform
- dry with materialThe organic layer was dried over anhydrous sodium sulfate
- customthe solvent was evaporated
출처 및 근거
- ORD 기록
- ord-20cce62618854ea4acacf3fd5d9a7e19
- 출처 데이터셋
- uspto-grants-1998_06
- 특허 번호
- US05767127
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