4-Amino-1-methylpiperidine → 4,8-bis-(2-chloro-phenyl)-2-(1-methyl-piperidin-4-ylamino)-8H-pyrido[2,3-d]pyrimidin-7-one

반응식

[CH3:30][N:31]1[CH2:32][CH2:33][CH:34]([NH2:37])[CH2:35][CH2:36]1.[Cl:1][c:2]1[c:3](-[c:8]2[c:9]3[c:10]([n:11][c:12]([S:14]([CH3:15])(=[O:16])=[O:17])[n:13]2)[n:18](-[c:23]2[c:24]([Cl:29])[cH:25][cH:26][cH:27][cH:28]2)[c:19](=[O:22])[cH:20][cH:21]3)[cH:4][cH:5][cH:6][cH:7]1>>[Cl:1][c:2]1[c:3](-[c:8]2[c:9]3[c:10]([n:11][c:12]([NH:37][CH:34]4[CH2:33][CH2:32][N:31]([CH3:30])[CH2:36][CH2:35]4)[n:13]2)[n:18](-[c:23]2[c:24]([Cl:29])[cH:25][cH:26][cH:27][cH:28]2)[c:19](=[O:22])[cH:20][cH:21]3)[cH:4][cH:5][cH:6][cH:7]1

참가 물질

반응물 2

HCID 27375314-Amino-1-methylpiperidine

HCID 102255784,8-bis-(2-chloro-phenyl)-2-methanesulfonyl-8H-pyrido[2,3-d]pyrimidin-7-one

생성물 1

HCID 101166844,8-bis-(2-chloro-phenyl)-2-(1-methyl-piperidin-4-ylamino)-8H-pyrido[2,3-d]pyrimidin-7-one

출처 및 근거

ORD 기록: ord-643e6decd1464fff838c11107ea0e09e
출처 데이터셋: Training data from https://doi.org/10.1039/C8SC04228D (2/10)
DOI: 10.1039/C8SC04228D

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