Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Thiazolidinedione → 5-(4-Chlorobenzylidene)-2,4-thiazolidinedione
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Thiazolidinedione | HCID 5437 | — |
| 반응물 | 4-Chlorobenzaldehyde | HCID 7726 | — |
| 반응물 | Piperidine | HCID 8082 | — |
| 용매 | Ethanol | HCID 702 | — |
| 생성물 | 5-(4-Chlorobenzylidene)-2,4-thiazolidinedione | HCID 233070 | 43.4% |
반응 단계
To a solution of 20 g (171 mmol) of 2,4-thiazolidinedione and 17.4 ml (171 mmol) of 4-chlorobenzaldehyde in 350 ml of ethanol, 1.68 ml (17.1 mmol) of piperidine was added, and the mixture was heated under reflux for 5 hours. After cooling, the precipitated crystals were filtered and washed with cooled ethanol to give 17.75 g of the desired compound (43.4% yield, pale yellow crystals).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05767121 |
| 출처 데이터셋 | uspto-grants-1998_06 |
| ORD ID | ord-8640849b69ac42fc9173ca6e5bbd63fe |
| 출처 메모 | uspto-grants-1998_06 |